A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression

• Main Authors: Martina Chrudinová (Author), Nicholas S. Kirk (Author), Aurelien Chuard (Author), Hari Venugopal (Author), Fa Zhang (Author), Marta Lubos (Author), Vasily Gelfanov (Author), Terezie Páníková (Author), Lenka Žáková (Author), Julianne Cutone (Author), Matthew Mojares (Author), Richard DiMarchi (Author), Jiří Jiráček (Author), Emrah Altindis (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The insulin/IGF superfamily is conserved across vertebrates and invertebrates. Our team has identified five viruses containing genes encoding viral insulin/IGF-1 like peptides (VILPs) closely resembling human insulin and IGF-1. This study aims to characterize the impact of Mandarin fish r...