Chimeric antigen receptor T cells targeting PD-L1 suppress tumor growth

• Main Authors: Le Qin (Author), Ruocong Zhao (Author), Dongmei Chen (Author), Xinru Wei (Author), Qiting Wu (Author), Youguo Long (Author), Zhiwu Jiang (Author), Yangqiu Li (Author), Haipeng Wu (Author), Xuchao Zhang (Author), Yilong Wu (Author), Shuzhong Cui (Author), Wei Wei (Author), Huihui Yao (Author), Zixia Liu (Author), Su Cao (Author), Yao Yao (Author), Zhenfeng Zhang (Author), Peng Li (Author)
• Format: Book
• Published: BMC, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Chimeric antigen receptor T cells (CAR-T cells) therapy has been well recognized for treating B cell-derived malignancy. However, the efficacy of CAR-T cells against solid tumors remains dissatisfactory, partially due to the heterogeneity of solid tumors and T cell exhaustion in...