Contribution of TRPA1 as a Downstream Signal of Proteinase-Activated Receptor-2 to Pancreatic Pain

• Main Authors: Yuka Terada (Author), Mayuko Fujimura (Author), Sachiyo Nishimura (Author), Maho Tsubota (Author), Fumiko Sekiguchi (Author), Hiroyuki Nishikawa (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined if TRPA1, like TRPV1, contributes to pancreatic nociceptor excitation following proteinase-activated receptor-2 (PAR2) stimulation and to pancreatitis-related pain in mice. A PAR2-activating peptide, infused into the pancreatic duct, caused spinal Fos expression, which was prevented by A...