Translating prognostic quantification of c-MYC and BCL2 from tissue microarrays to whole slide images in diffuse large B-cell lymphoma using deep learning

• Main Authors: Thomas E. Tavolara (Author), M. Khalid Khan Niazi (Author), Andrew L. Feldman (Author), David L. Jaye (Author), Christopher Flowers (Author), Lee A.D. Cooper (Author), Metin N. Gurcan (Author)
• Format: Book
• Published: BMC, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background c-MYC and BCL2 positivity are important prognostic factors for diffuse large B-cell lymphoma. However, manual quantification is subject to significant intra- and inter-observer variability. We developed an automated method for quantification in whole-slide images of tissue sectio...