Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs

• Main Authors: Kazue Kasai (Author), Hiroshi Nakashima (Author), Fang Liu (Author), Samantha Kerr (Author), Jiang Wang (Author), Mitch Phelps (Author), Philip M Potter (Author), William B Goins (Author), Soledad A Fernandez (Author), E Antonio Chiocca (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MGH2.1 is a herpes simplex virus type 1 (HSV1) oncolytic virus that expresses two prodrug-activating transgenes: the cyclophosphamide (CPA)-activating cytochrome P4502B1 (CYP2B1) and the CPT11-activating secreted human intestinal carboxylesterase (shiCE). Toxicology and biodistribution of MGH2.1 in...