Large-scale data mining of four billion human antibody variable regions reveals convergence between therapeutic and natural antibodies that constrains search space for biologics drug discovery

• Main Authors: Pawel Dudzic (Author), Dawid Chomicz (Author), Jarosław Kończak (Author), Tadeusz Satława (Author), Bartosz Janusz (Author), Sonia Wrobel (Author), Tomasz Gawłowski (Author), Igor Jaszczyszyn (Author), Weronika Bielska (Author), Samuel Demharter (Author), Roberto Spreafico (Author), Lukas Schulte (Author), Kyle Martin (Author), Stephen R. Comeau (Author), Konrad Krawczyk (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The naïve human antibody repertoire has theoretical access to an estimated > 1015 antibodies. Identifying subsets of this prohibitively large space where therapeutically relevant antibodies may be found is useful for development of these agents. It was previously demonstrated that, despite the im...