Alcoholic hepatitis and metabolic disturbance in female mice: a more tractable model than Nrf2−/− animals

• Main Authors: Lozan Sheriff (Author), Reenam S. Khan (Author), Raquel Saborano (Author), Richard Wilkin (Author), Nguyet-Thin Luu (Author), Ulrich L. Gunther (Author), Stefan G. Hubscher (Author), Philip N. Newsome (Author), Patricia F. Lalor (Author)
• Format: Book
• Published: The Company of Biologists, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alcoholic hepatitis (AH) is the dramatic acute presentation of alcoholic liver disease, with a 15% mortality rate within 28 days in severe cases. Research into AH has been hampered by the lack of effective and reproducible murine models that can be operated under different regulatory frameworks inte...