Population pharmacokinetics of Amisulpride in Chinese patients with schizophrenia with external validation: the impact of renal function

• Main Authors: Anning Li (Author), Wen Yao Mak (Author), Tingyi Ruan (Author), Fang Dong (Author), Nan Zheng (Author), Meng Gu (Author), Wei Guo (Author), Jingye Zhang (Author), Haoxuan Cheng (Author), Canjun Ruan (Author), Yufei Shi (Author), Yannan Zang (Author), Xuequan Zhu (Author), Qingfeng He (Author), Xiaoqiang Xiang (Author), Gang Wang (Author), Xiao Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Amisulpride is primarily eliminated via the kidneys. Given the clear influence of renal clearance on plasma concentration, we aimed to explicitly examine the impact of renal function on amisulpride pharmacokinetics (PK) via population PK modelling and Monte Carlo simulations.Method: Pl...