A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice

• Asıl Yazarlar: Wei Li (Yazar), Alba Bellot-Saez (Yazar), Mary L. Phillips (Yazar), Tao Yang (Yazar), Frank M. Longo (Yazar), Lucas Pozzo-Miller (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2017-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in methyl-CpG-binding protein-2 (MECP2), a transcriptional regulator of many genes, including brain-derived neurotrophic factor (BDNF). BDNF levels are reduced in RTT autopsy brains and in multiple brain areas of Mecp2-deficien...