Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60

• 主要な著者: Atsushi Yamauchi (著者), Takanobu Ichimiya (著者), Kouichi Inoue (著者), Yukie Taguchi (著者), Naoya Matsunaga (著者), Satoru Koyanagi (著者), Tatsuo Fukagawa (著者), Hironori Aramaki (著者), Shun Higuchi (著者), Shigehiro Ohdo (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2005-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The role of the susceptibility of cells and the pharmacokinetics of MTX on the time-dependent change of methotrexate (MTX) pharmacologic action in HL-60 (human leukemia cell) was investigated from the viewpoints of the rhythm of DNA synthesis. The highest activity of MTX was observed at the time whe...