Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60

Cell-Cycle-Dependent Pharmacology of Methotrexate in HL-60

The role of the susceptibility of cells and the pharmacokinetics of MTX on the time-dependent change of methotrexate (MTX) pharmacologic action in HL-60 (human leukemia cell) was investigated from the viewpoints of the rhythm of DNA synthesis. The highest activity of MTX was observed at the time whe...

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Main Authors: Atsushi Yamauchi (Author), Takanobu Ichimiya (Author), Kouichi Inoue (Author), Yukie Taguchi (Author), Naoya Matsunaga (Author), Satoru Koyanagi (Author), Tatsuo Fukagawa (Author), Hironori Aramaki (Author), Shun Higuchi (Author), Shigehiro Ohdo (Author)
Format: Book
Published: Elsevier, 2005-01-01T00:00:00Z.
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