Proteomics and phosphoproteomics study of LCMT1 overexpression and oxidative stress: overexpression of LCMT1 arrests H2O2-induced lose of cells viability

• Main Authors: Xinhang Wang (Author), Shen Tang (Author), Fu Qin (Author), Yuyang Liu (Author), Ziwei Liang (Author), Haiqing Cai (Author), Laiming Mo (Author), Deqiang Xiao (Author), Songcao Guo (Author), Yiqiang Ouyang (Author), Bin Sun (Author), Cailing Lu (Author), Xiyi Li (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase, is also known to be a target of ROS. The methylation of PP2A can be catalyzed by leucine carboxyl methyltransferase-1 (LCMT1), which regulates PP2A activity and substrate specificity. Methods: In the previous study, we...