Genome-Wide Mapping of Bivalent Histone Modifications in Hepatic Stem/Progenitor Cells

• Main Authors: Kengo Kanayama (Author), Tetsuhiro Chiba (Author), Motohiko Oshima (Author), Hiroaki Kanzaki (Author), Shuhei Koide (Author), Atsunori Saraya (Author), Satoru Miyagi (Author), Naoya Mimura (Author), Yuko Kusakabe (Author), Tomoko Saito (Author), Sadahisa Ogasawara (Author), Eiichiro Suzuki (Author), Yoshihiko Ooka (Author), Hitoshi Maruyama (Author), Atsushi Iwama (Author), Naoya Kato (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The "bivalent domain," a distinctive histone modification signature, is characterized by repressive trimethylation of histone H3 at lysine 27 (H3K27me3) and active trimethylation of histone H3 at lysine 4 (H3K4me3) marks. Maintenance and dynamic resolution of these histone marks play impor...