Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions

• Main Authors: Hongwei Zhang (Author), Minglu Li (Author), Jianmin Li (Author), Anjali Agrawal (Author), Ho-Wah Hui (Author), Demin Liu (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound. A total of 30% Fenofibrate-loaded mesoporous silica and s...