Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain

• Main Authors: Kristina Wardelmann (Author), Sabine Blümel (Author), Michaela Rath (Author), Eugenia Alfine (Author), Chantal Chudoba (Author), Mareike Schell (Author), Weikang Cai (Author), Robert Hauffe (Author), Kathrin Warnke (Author), Tanina Flore (Author), Katrin Ritter (Author), Jürgen Weiß (Author), C. Ronald Kahn (Author), André Kleinridders (Author)
• Format: Book
• Published: Elsevier, 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin action in the brain controls metabolism and brain function, which is linked to proper mitochondrial function. Conversely, brain insulin resistance associates with mitochondrial stress and metabolic and neurodegenerative diseases. In the present study, we aimed to decipher the impa...