Aberrant overexpression of HOTAIR inhibits abdominal adipogenesis through remodelling of genome-wide DNA methylation and transcription

• Main Authors: Feng-Chih Kuo (Author), Yu-Chun Huang (Author), Ming-Ren Yen (Author), Chien-Hsing Lee (Author), Kuo-Feng Hsu (Author), Hsiang-Yu Yang (Author), Li-Wei Wu (Author), Chieh-Hua Lu (Author), Yu-Juei Hsu (Author), Pao-Yang Chen (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Abdominal adiposity is strongly associated with diabetic and cardiovascular comorbidities. The long noncoding RNA HOTAIR (HOX Transcript Antisense Intergenic RNA) is an important epigenetic regulator with fat depot-specific expression. Its functional roles and epigenetic regulation in abd...