Downregulation of Hypoxia-Inducible Factor-1α by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats

• Main Authors: Yiping Hu (Author), Tiantian Zhang (Author), Jingqin Chen (Author), WenXiang Cheng (Author), Jianhai Chen (Author), Zhengtan Zheng (Author), Jietao Lin (Author), Guoyuan Zhu (Author), Yong Zhang (Author), Xueling Bai (Author), Yan Wang (Author), Bing Song (Author), Qingwen Wang (Author), Ling Qin (Author), Peng Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rheumatoid arthritis (RA) is the most common type of autoimmune arthritis. Hypoxia-inducible factor-1α (HIF-1α) as a transcription factor in response to hypoxia suggests that it could be a potential therapeutic target for the treatment of RA. In this study, we assessed whether the HIF pathway blocka...