Synthesis and cytotoxic activity of per-acetylated and halogenated derivatives of nucleosides in breast cancer cells

• Principais autores: JF Berrío Escobar (Autor), MH Pastrana Restrepo (Autor), E Galeano Jaramillo (Autor), DM Márquez Fernández (Autor), ME Márquez Fernández (Autor), A Martínez Martínez (Autor)
• Formato: Livro
• Publicado em: Facultad de Farmacia, Universidad de Granada.
• Assuntos: article
• Acesso em linha: Connect to this object online.

ABSTRACT Objectives: To make the synthesis of halogenated derivatives on the nitrogenous base and their respective acyl ester and amide type derivatives for all hydroxyl and amine groups of the uridine and cytarabine nucleosides, and evaluate cytotoxicity against breast cancer cell line. Methods: Fi...