Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

<p>Abstract</p> <p>Background</p> <p>The Janus kinase (JAK) family of tyrosine kinases includes JAK1, JAK2, JAK3 and TYK2, and is required for signaling through Type I and Type II cytokine receptors. CP-690,550 is a potent and selective JAK inhibitor currently in clinic...

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Main Authors: Meyer Debra M (Author), Jesson Michael I (Author), Li Xiong (Author), Elrick Mollisa M (Author), Funckes-Shippy Christie L (Author), Warner James D (Author), Gross Cindy J (Author), Dowty Martin E (Author), Ramaiah Shashi K (Author), Hirsch Jeffrey L (Author), Saabye Matthew J (Author), Barks Jennifer L (Author), Kishore Nandini (Author), Morris Dale L (Author)
Format: Book
Published: BMC, 2010-08-01T00:00:00Z.
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