Reducing kidney uptake of radiolabelled exendin-4 using variants of the renally cleavable linker MVK

Abstract Background Peptidic radiotracers are preferentially excreted through the kidneys, which often results in high persistent renal retention of radioactivity, limiting or even preventing therapeutic clinical translation of these radiotracers. Exendin-4, which targets the glucagon-like-peptide 1...

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Main Authors: Belinda Trachsel (Author), Giulia Valpreda (Author), Alexandra Lutz (Author), Roger Schibli (Author), Linjing Mu (Author), Martin Béhé (Author)
Format: Book
Published: SpringerOpen, 2023-09-01T00:00:00Z.
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