NPC 15669 blocks neutrophil CD18 increase and lung injury during cardiopulmonary bypass in pigs

• Main Authors: J. M. Bator (Author), A. M. Gillinov (Author), K. J. Zehr (Author), J. M. Redmond (Author), I. C. Wilson (Author), A. Herskowitz (Author), J. R. Connor (Author), R. M. Burch (Author), D. E. Cameron (Author)
• Format: Book
• Published: Hindawi Limited, 1993-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During cardiopulmonary bypass (CPB), neutrophils become activated due to contact with extracorporeal surfaces and binding of complement fragments C3a and C5a, leading to extravasation and subsequent tissue damage. In this study, the effects of the leumedin NPC 15669 (N [9H - (2,7 dimethylfluorenyl -...