Natural Antioxidant-Isoliquiritigenin Ameliorates Contractile Dysfunction of Hypoxic Cardiomyocytes via AMPK Signaling Pathway

• Main Authors: Xiaoyu Zhang (Author), Ping Zhu (Author), Xiuying Zhang (Author), Yina Ma (Author), Wenguang Li (Author), Ji-Mei Chen (Author), Hui-Ming Guo (Author), Richard Bucala (Author), Jian Zhuang (Author), Ji Li (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isoliquiritigenin (ISL), a simple chalcone-type flavonoid, is derived from licorice compounds and is mainly present in foods, beverages, and tobacco. Reactive oxygen species (ROS) is a critical factor involved in modulating cardiac stress response signaling during ischemia and reperfusion. We hypoth...