Pharmacophore-based virtual screening approaches to identify novel molecular candidates against EGFR through comprehensive computational approaches and in-vitro studies

• Main Authors: F A Dain Md Opo (Author), Mohammed Moulay (Author), Ali Zari (Author), Afnan Alqaderi (Author), Saleh Alkarim (Author), Talal Zari (Author), Mohiuddin Ahmed Bhuiyan (Author), Maged Mostafa Mahmoud (Author), Fadwa Aljoud (Author), Mohd Suhail (Author), Sherif Edris (Author), Wafaa S. Ramadan (Author), Mohammad Amjad Kamal (Author), Saïd Nemmiche (Author), Foysal Ahammad (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alterations to the EGFR (epidermal growth factor receptor) gene, which primarily occur in the axon 18-21 position, have been linked to a variety of cancers, including ovarian, breast, colon, and lung cancer. The use of TK inhibitors (gefitinib, erlotinib, lapatinib, and afatinib) and monoclonal anti...