Formyl Peptide Receptor 1 and 2 Dual Agonist Inhibits Human Neutrophil Chemotaxis by the Induction of Chemoattractant Receptor Cross-desensitization

• Autori principali: Yoshitaka Sogawa (Autore), Takao Ohyama (Autore), Hiroaki Maeda (Autore), Kazuki Hirahara (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2011-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Formyl peptide receptor 1 (FPR1) and FPR2/ALX are known to control neutrophil chemotaxis in response to various ligands. In this study, we investigated the inhibitory mechanism of compound 43 (Cpd43), an FPR1 and FPR2/ALX dual agonist, on human neutrophil chemotaxis. Precedent stimulation of human p...