Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway

• المؤلفون الرئيسيون: M. Rizwan Siddiqui (مؤلف), Narsa M. Reddy (مؤلف), Hafeez M. Faridi (مؤلف), Mohd Shahid (مؤلف), Thomas P. Shanley (مؤلف)
• التنسيق: كتاب
• منشور في: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Background: Microvascular endothelial hyperpermeability is an earliest pathological hallmark in Acute Lung Injury (ALI), which progressively leads to Acute Respiratory Distress Syndrome (ARDS). Recently, vascular protective and anti-inflammatory effect of metformin, irrespective of glycemic control,...