Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia

• Main Authors: Alexander P. de Porto (Author), Zhe Liu (Author), Regina de Beer (Author), Sandrine Florquin (Author), Onno J. de Boer (Author), Rudi W. Hendriks (Author), Tom van der Poll (Author), Alex F. de Vos (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (Btk), a key signaling pr...