Changes in cystic fibrosis transmembrane conductance regulator protein expression prior to and during elexacaftor-tezacaftor-ivacaftor therapy

• Main Authors: Frauke Stanke (Author), Sophia T. Pallenberg (Author), Stephanie Tamm (Author), Silke Hedtfeld (Author), Ella M. Eichhorn (Author), Rebecca Minso (Author), Gesine Hansen (Author), Tobias Welte (Author), Annette Sauer-Heilborn (Author), Felix C. Ringshausen (Author), Sibylle Junge (Author), Burkhard Tümmler (Author), Anna-Maria Dittrich (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Defects in expression, maturation or function of the epithelial membrane glycoprotein CFTR are causative for the progressive disease cystic fibrosis. Recently, molecular therapeutics that improve CFTR maturation and functional defects have been approved. We aimed to verify whether we cou...