Protein photodegradation in the visible range? Insights into protein photooxidation with respect to protein concentration

• Main Authors: Elena Hipper (Author), Florian Lehmann (Author), Wolfgang Kaiser (Author), Göran Hübner (Author), Julia Buske (Author), Michaela Blech (Author), Dariush Hinderberger (Author), Patrick Garidel (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Visible light (400-800 nm) can lead to photooxidation of protein formulations, which might impair protein integrity. However, the relevant mechanism of photooxidation upon visible light exposure is still unclear for therapeutic proteins, since proteinogenic structures do not absorb light in the visi...