Revisiting the nature and pharmacodynamics of tacrolimus metabolites

• 主要な著者: Rudy Mevizou (著者), Hassan Aouad (著者), François-Ludovic Sauvage (著者), Hélène Arnion (著者), Emilie Pinault (著者), Jean-Sébastien Bernard (著者), Gildas Bertho (著者), Nicolas Giraud (著者), Rodolphe Alves de Sousa (著者), Adolfo Lopez-Noriega (著者), Florent Di Meo (著者), Mélanie Campana (著者), Pierre Marquet (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2024-11-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The toxicity of tacrolimus metabolites and their potential pharmacodynamic (PD) interactions with tacrolimus might respectively explain the surprising combination of higher toxicity and lower efficacy of tacrolimus despite normal blood concentrations, described in extensive metabolizers. To evaluate...