Revisiting the nature and pharmacodynamics of tacrolimus metabolites

Revisiting the nature and pharmacodynamics of tacrolimus metabolites

The toxicity of tacrolimus metabolites and their potential pharmacodynamic (PD) interactions with tacrolimus might respectively explain the surprising combination of higher toxicity and lower efficacy of tacrolimus despite normal blood concentrations, described in extensive metabolizers. To evaluate...

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Main Authors: Rudy Mevizou (Author), Hassan Aouad (Author), François-Ludovic Sauvage (Author), Hélène Arnion (Author), Emilie Pinault (Author), Jean-Sébastien Bernard (Author), Gildas Bertho (Author), Nicolas Giraud (Author), Rodolphe Alves de Sousa (Author), Adolfo Lopez-Noriega (Author), Florent Di Meo (Author), Mélanie Campana (Author), Pierre Marquet (Author)
Format: Book
Published: Elsevier, 2024-11-01T00:00:00Z.
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