Inhibitory Effect of Lomerizine, a Prophylactic Drug for Migraines, on Serotonin-Induced Contraction of the Basilar Artery

• Main Authors: Masakazu Ishii (Author), Shunsuke Kobayashi (Author), Masamichi Ohkura (Author), Ryuichi Yamamoto (Author), Shunichi Shimizu (Author), Yuji Kiuchi (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We examined the effects of lomerizine on serotonin (5-hydroxytryptamine, 5-HT)- induced contraction of the basilar artery and compared them with those of nifedipine. Although both lomerizine and nifedipine completely blocked K+-induced vasoconstriction, 5-HT-induced vasoconstriction was more strongl...