Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice

• Main Authors: Hirofumi Matsubara (Author), Takahiko Imai (Author), Shohei Tsuji (Author), Natsumi Oka (Author), Yusuke Egashira (Author), Yukiko Enomoto (Author), Noriyuki Nakayama (Author), Shinsuke Nakamura (Author), Masamitsu Shimazawa (Author), Toru Iwama (Author), Hideaki Hara (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study aimed to evaluate the effects of nafamostat, a serin protease inhibitor, in the management of subarachnoid hemorrhage (SAH). SAH was induced by endovascular perforation in male mice. Nafamostat was administered intraperitoneally four times immediately after SAH induction. Cerebral blood f...