Anilinoquinoline based inhibitors of trypanosomatid proliferation.

• Główni autorzy: Lori Ferrins (Autor), Amrita Sharma (Autor), Sarah M Thomas (Autor), Naimee Mehta (Autor), Jessey Erath (Autor), Scott Tanghe (Autor), Susan E Leed (Autor), Ana Rodriguez (Autor), Kojo Mensa-Wilmot (Autor), Richard J Sciotti (Autor), Kirsten Gillingwater (Autor), Michael P Pollastri (Autor)
• Format: Książka
• Wydane: Public Library of Science (PLoS), 2018-11-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which...