Anilinoquinoline based inhibitors of trypanosomatid proliferation.

Anilinoquinoline based inhibitors of trypanosomatid proliferation.

We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which...

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Main Authors: Lori Ferrins (Author), Amrita Sharma (Author), Sarah M Thomas (Author), Naimee Mehta (Author), Jessey Erath (Author), Scott Tanghe (Author), Susan E Leed (Author), Ana Rodriguez (Author), Kojo Mensa-Wilmot (Author), Richard J Sciotti (Author), Kirsten Gillingwater (Author), Michael P Pollastri (Author)
Format: Book
Published: Public Library of Science (PLoS), 2018-11-01T00:00:00Z.
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