Anilinoquinoline based inhibitors of trypanosomatid proliferation.

• Main Authors: Lori Ferrins (Author), Amrita Sharma (Author), Sarah M Thomas (Author), Naimee Mehta (Author), Jessey Erath (Author), Scott Tanghe (Author), Susan E Leed (Author), Ana Rodriguez (Author), Kojo Mensa-Wilmot (Author), Richard J Sciotti (Author), Kirsten Gillingwater (Author), Michael P Pollastri (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent compounds against Trypanosoma brucei brucei (which...