Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine

• Main Authors: Carrie A Vyhlidal (Author), Brian D. Chapron (Author), Atif Ahmed (Author), Vivekanand Singh (Author), Rebecca Casini (Author), Valentina Shakhnovich (Author)
• Format: Book
• Published: Wiley, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Changes in absorptive capacity and first‐pass metabolism in the small intestine affect oral drug bioavailability. Characterization of such changes as a consequence of inflammation is important for developing physiologically‐based pharmacokinetic (PBPK) models for inflammatory bowel disease. We sough...