Metformin induces muscle atrophy by transcriptional regulation of myostatin via HDAC6 and FoxO3a

• Main Authors: Min Ju Kang (Author), Ji Wook Moon (Author), Jung Ok Lee (Author), Ji Hae Kim (Author), Eun Jeong Jung (Author), Su Jin Kim (Author), Joo Yeon Oh (Author), Sang Woo Wu (Author), Pu Reum Lee (Author), Sun Hwa Park (Author), Hyeon Soo Kim (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Skeletal muscle atrophy is a severe condition that involves loss of muscle mass and quality. Drug intake can also cause muscle atrophy. Biguanide metformin is the first‐line and most widely prescribed anti‐diabetic drug for patients with type 2 diabetes. The molecular mechanism o...