Transient and tunable CRISPRa regulation of APOBEC/AID genes for targeting hepatitis B virus

• Main Authors: Dmitry Kostyushev (Author), Sergey Brezgin (Author), Anastasiya Kostyusheva (Author), Natalia Ponomareva (Author), Ekaterina Bayurova (Author), Natalia Zakirova (Author), Alla Kondrashova (Author), Irina Goptar (Author), Anastasiya Nikiforova (Author), Anna Sudina (Author), Yurii Babin (Author), Ilya Gordeychuk (Author), Alexander Lukashev (Author), Andrey A. Zamyatnin, Jr (Author), Alexander Ivanov (Author), Vladimir Chulanov (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

APOBEC/AID cytidine deaminases play an important role in innate immunity and antiviral defenses and were shown to suppress hepatitis B virus (HBV) replication by deaminating and destroying the major form of HBV genome, covalently closed circular DNA (cccDNA), without toxicity to the infected cells....