The molecular pathogenesis of triptolide-induced hepatotoxicity

• Main Authors: Yeqing Hu (Author), Qiguo Wu (Author), Yulin Wang (Author), Haibo Zhang (Author), Xueying Liu (Author), Hua Zhou (Author), Tao Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP) is the major pharmacologically active ingredient and toxic component of Tripterygium wilfordii Hook. f. However, its clinical potential is limited by a narrow therapeutic window and multiple organ toxicity, especially hepatotoxicity. Furthermore, TP-induced hepatotoxicity shows signi...