Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

• Главные авторы: Sibusiso Maseko (Автор), Eden Padayachee (Автор), Siyabonga Maphumulo (Автор), Thavendran Govender (Автор), Yasien Sayed (Автор), Glenn Maguire (Автор), Johnson Lin (Автор), Tricia Naicker (Автор), Sooraj Baijnath (Автор), Kruger Hendrik Gerhardus (Автор)
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• Опубликовано: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Предметы: article
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Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five mutations, E35D, two insertions, position 36 (G and S), and D60E. Kinetics, inhibition constants, vitality, Gibbs free binding energies are reported...