Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

• Main Authors: Sibusiso Maseko (Author), Eden Padayachee (Author), Siyabonga Maphumulo (Author), Thavendran Govender (Author), Yasien Sayed (Author), Glenn Maguire (Author), Johnson Lin (Author), Tricia Naicker (Author), Sooraj Baijnath (Author), Kruger Hendrik Gerhardus (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Herein, we report the effect of nine FDA approved protease inhibitor drugs against a new HIV-1 subtype C mutant protease, E35D↑G↑S. The mutant has five mutations, E35D, two insertions, position 36 (G and S), and D60E. Kinetics, inhibition constants, vitality, Gibbs free binding energies are reported...