Clonal evolution and therapeutic resistance in solid tumors

• Main Authors: Elizabeth eLenkiewicz (Author), Lisa eEvers (Author), Tara eHolley (Author), Christian eRuiz (Author), Lukas eBubendorf (Author), Aleksander eSekulic (Author), Ramesh K Ramanathan (Author), Daniel D Von Hoff (Author), Michael T Barrett (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumors frequently arise as a result of an acquired genomic instability and the subsequent evolution of neoplastic populations with variable genomes. A barrier to the study of the somatic genetics of human solid tumors in vivo is the presence of admixtures of non-neoplastic cells with normal genomes...