Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells.

• Main Authors: Subash Babu (Author), Sajid Q Bhat (Author), N Pavan Kumar (Author), Angelo B Lipira (Author), Sanath Kumar (Author), C Karthik (Author), V Kumaraswami (Author), Thomas B Nutman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients.To elucidate the role of CD4(+) T cell subsets in the development of lymphatic pathology, we examined specific sets of cytokines in in...