Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds-synthesis, biological activity, and structural evaluation

• Main Authors: Piotr Stępnicki (Author), Olga Wronikowska-Denysiuk (Author), Agata Zięba (Author), Katarzyna M. Targowska-Duda (Author), Agata Bartyzel (Author), Martyna Z. Wróbel (Author), Tomasz M. Wróbel (Author), Klaudia Szałaj (Author), Andrzej Chodkowski (Author), Karolina Mirecka (Author), Barbara Budzyńska (Author), Emilia Fornal (Author), Jadwiga Turło (Author), Marián Castro (Author), Agnieszka A. Kaczor (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Schizophrenia is a chronic mental disorder that is not satisfactorily treated with available antipsychotics. The presented study focuses on the search for new antipsychotics by optimising the compound D2AAK3, a multi-target ligand of G-protein-coupled receptors (GPCRs), in particular D2, 5-HT1A, and...