A tanshinone IIA derivative designed to target mitochondria inhibit myocardial ischemia/reperfusion injury in vivo in a GUF1 dependent- pathway

• Main Authors: Wen Zhou (Author), Keyu Fan (Author), Xiaojian Yin (Author), Yuxuan Wang (Author), Yuyao Zhang (Author), Shaohua Gou (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondrial dysfunction is the common pathological basis of myocardial ischemia/reperfusion (I/R) injury, which induces an intriguing study on mitochondrial-targeting compounds to treat mitochondrial dysfunction related diseases. Herein, a novel mitochondrial targeting compound Tan-TPP was synthes...