The mitochondrial pyruvate carrier regulates adipose glucose partitioning in female mice

• Main Authors: Christopher E. Shannon (Author), Terry Bakewell (Author), Marcel J. Fourcaudot (Author), Iriscilla Ayala (Author), Annie A. Smelter (Author), Edgar A. Hinostroza (Author), Giovanna Romero (Author), Mara Asmis (Author), Leandro C. Freitas Lima (Author), Martina Wallace (Author), Luke Norton (Author)
• Format: Book
• Published: Elsevier, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The mitochondrial pyruvate carrier (MPC) occupies a critical node in intermediary metabolism, prompting interest in its utility as a therapeutic target for the treatment of obesity and cardiometabolic disease. Dysregulated nutrient metabolism in adipose tissue is a prominent feature of ob...