Development of caspase-3-selective activity-based probes for PET imaging of apoptosis

• Main Authors: Louis Lauwerys (Author), Lucas Beroske (Author), Angelo Solania (Author), Christel Vangestel (Author), Alan Miranda (Author), Nele Van Giel (Author), Karuna Adhikari (Author), Anne-Marie Lambeir (Author), Leonie wyffels (Author), Dennis Wolan (Author), Pieter Van der Veken (Author), Filipe Elvas (Author)
• Format: Book
• Published: SpringerOpen, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The cysteine-aspartic acid protease caspase-3 is recognized as the main executioner of apoptosis in cells responding to specific extrinsic and intrinsic stimuli. Caspase-3 represents an interesting biomarker to evaluate treatment response, as many cancer therapies exert their eff...