First-in-human study assessing safety, tolerability, and pharmacokinetics of 2-hydroxybenzylamine acetate, a selective dicarbonyl electrophile scavenger, in healthy volunteers

• Main Authors: Lisa M. Pitchford (Author), John A. Rathmacher (Author), John C. Fuller (Author), J. Scott Daniels (Author), Ryan D. Morrison (Author), Wendall S. Akers (Author), Naji N. Abumrad (Author), Venkataraman Amarnath (Author), Patricia M. Currey (Author), L. Jackson Roberts (Author), John A. Oates (Author), Olivier Boutaud (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background 2-Hydroxybenzylamine (2-HOBA) is a selective scavenger of dicarbonyl electrophiles that protects proteins and lipids from being modified by these electrophiles. It is currently being developed for use as a nutritional supplement to help maintain good health and protect against th...