Physiologically based mechanistic insight into differential risk of valproate hepatotoxicity between children and adults: A focus on ontogeny impact

Abstract The anticonvulsant valproic acid (VPA) despite complex pharmacokinetics has been in clinical use for nearly 6 decades. Previous reports indicated neonates, infants, and toddlers/preschoolers had higher risk of valproate hepatotoxicity than adults. However, dosing recommendations for those l...

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Main Authors: Yu‐Ting Huang (Author), Yen‐Ming Huang (Author), Fan‐Lu Kung (Author), Chun‐Jung Lin (Author), Tun Jao (Author), Yunn‐Fang Ho (Author)
Format: Book
Published: Wiley, 2023-12-01T00:00:00Z.
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