Physiologically based mechanistic insight into differential risk of valproate hepatotoxicity between children and adults: A focus on ontogeny impact
Abstract The anticonvulsant valproic acid (VPA) despite complex pharmacokinetics has been in clinical use for nearly 6 decades. Previous reports indicated neonates, infants, and toddlers/preschoolers had higher risk of valproate hepatotoxicity than adults. However, dosing recommendations for those l...
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| Main Authors: | , , , , , |
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| Format: | Book |
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Wiley,
2023-12-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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