Physiologically‐Based Pharmacokinetic Modeling of Fluconazole Using Plasma and Cerebrospinal Fluid Samples From Preterm and Term Infants

• Main Authors: Jacqueline G. Gerhart (Author), Kevin M. Watt (Author), Andrea Edginton (Author), Kelly C. Wade (Author), Sara N. Salerno (Author), Daniel K. Benjamin Jr (Author), P. Brian Smith (Author), Christoph P. Hornik (Author), Michael Cohen‐Wolkowiez (Author), Shahnaz Duara (Author), Ashley Ross (Author), Karen Shattuck (Author), Dan L. Stewart (Author), Natalie Neu (Author), Daniel Gonzalez (Author), the Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fluconazole is used to treat hematogenous Candida meningoencephalitis in preterm and term infants. To characterize plasma and central nervous system exposure, an adult fluconazole physiologically‐based pharmacokinetic (PBPK) model was scaled to infants, accounting for age dependencies in glomerular...