L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats

• Main Authors: Natália Valadares de Moraes (Author), Mateus Machado Bergamaschi (Author), Maria de Lourdes Pires Bianchi (Author), Juliana Bordinassi Bragheto (Author), Wilson Roberto Malfará (Author), Regina Helena Costa Queiroz (Author)
• Format: Book
• Published: Universidade de São Paulo, 2012-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system. The aim of the present study was to evaluate the influence of L-arginine supplementation, a precursor for the sy...