L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats

• Hlavní autoři: Natália Valadares de Moraes (Autor), Mateus Machado Bergamaschi (Autor), Maria de Lourdes Pires Bianchi (Autor), Juliana Bordinassi Bragheto (Autor), Wilson Roberto Malfará (Autor), Regina Helena Costa Queiroz (Autor)
• Médium: Kniha
• Vydáno: Universidade de São Paulo, 2012-03-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system. The aim of the present study was to evaluate the influence of L-arginine supplementation, a precursor for the sy...