Influence of Oxidative Stress Biomarkers and Genetic Polymorphisms on the Clinical Severity of Hydroxyurea-Free Senegalese Children with Sickle Cell Anemia

• Main Authors: Fatou Gueye Tall (Author), Cyril Martin (Author), El hadji Malick Ndour (Author), Camille Faes (Author), Indou Déme Ly (Author), Vincent Pialoux (Author), Philippe Connes (Author), Papa Madieye Gueye (Author), Rokhaya Ndiaye Diallo (Author), Céline Renoux (Author), Ibrahima Diagne (Author), Pape Amadou Diop (Author), Aynina Cissé (Author), Philomène Lopez Sall (Author), Philippe Joly (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress would play a role in the pathophysiology of sickle cell anemia (SCA). We tested the impact of common SCA genetic modifiers (alpha-thalassemia, G6PD deficiency, HbF quantitative trait loci; QTL) and pro/antioxidant genes polymorphisms (<i>SOD2</i> rs4880, <i>XO</...